Congenital heart disease is the most frequent birth defect and the leading cause of death for
the fetus and in the first year of life. The wide phenotypic diversity of congenital heart defects …

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential
developmental programs. Twist-family bHLH proteins function by dimerizing with other …

Reentry is the main mechanism of life-threatening ventricular arrhythmias, including
ventricular fibrillation and tachycardia. Its occurrence depends on the simultaneous …

Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA)
in animals remain challenging. Here, using multiple knockout mouse models and single cell …

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …

The basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac
development both in neural crest-derived and mesoderm-derived structures. Targeted …

Objective—CCN1 (Cyr61) is an extracellular matrix-associated protein involved in cell
proliferation and survival. CCN1 is bound to vascular smooth muscle cells (VSMCs) via …

CCN1 (Cyr61) is a secreted matricellular protein, mediating angiogenesis and cell survival
through interaction with integrins. Although CCN1 expression is induced in the heart during …

Autophagy is simultaneously a mode of programmed cell death and an important
physiological process for cell survival, but its pathophysiological significance in cardiac …

The basic helix-loop-helix (bHLH) transcription factor Hand2 is required for growth and
development of the heart, branchial arches and limb buds. To determine whether DNA …