Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl

EA Kiyatkin - Neuropharmacology, 2019 - Elsevier
Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …

[HTML][HTML] Pain management in the emergency department: a review article on options and methods

A Abdolrazaghnejad, M Banaie, N Tavakoli… - Advanced journal of …, 2018 - ncbi.nlm.nih.gov
Results: For better understanding, the results are reported in to separate subheadings
including “Parenteral agents” and “Regional blocks”. Non-opioids analgesics such as …

Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients

PE Bijur, MK Kenny, EJ Gallagher - Annals of emergency medicine, 2005 - Elsevier
STUDY OBJECTIVE: The objective was to quantify the analgesic effect of a dose of
intravenous morphine, 0.1 mg/kg, to emergency department (ED) patients presenting in …

Safety and efficacy of hydromorphone as an analgesic alternative to morphine in acute pain: a randomized clinical trial

AK Chang, PE Bijur, RH Meyer, MK Kenny… - Annals of emergency …, 2006 - Elsevier
STUDY OBJECTIVE: We compare a standard weight-based dose of intravenous
hydromorphone (Dilaudid) to a standard weight-based dose of intravenous morphine in …

Self‐reported pain scores in the emergency department: lack of association with vital signs

CA Marco, MC Plewa, N Buderer… - Academic …, 2006 - Wiley Online Library
Background: Some practitioners and investigators have presumed relationships between
pain scores and heart rate, blood pressure, or respiratory rate. Previous literature has not …

Randomized double-blind placebo-controlled trial of two intravenous morphine dosages (0.10 mg/kg and 0.15 mg/kg) in emergency department patients with …

A Birnbaum, D Esses, PE Bijur, L Holden… - Annals of emergency …, 2007 - Elsevier
STUDY OBJECTIVE: We compare pain relief and safety of morphine 0.10 mg/kg with 0.15
mg/kg in adult emergency department (ED) patients with acute pain. METHODS: This was a …

Is there an ideal morphine dose for prehospital treatment of severe acute pain? A randomized, double-blind comparison of 2 doses

V Bounes, S Charpentier, CH Houze-Cerfon… - The American journal of …, 2008 - Elsevier
STUDY OBJECTIVE: We aimed to determine the best intravenous morphine titration protocol
by comparing 2 protocols for prehospital treatment of patients with severe acute pain …

The drug-seeking patient in the emergency room

GR Hansen - Emergency Medicine Clinics, 2005 - emed.theclinics.com
It has been estimated that an emergency department with 75,000 patients per year can
expect up to 262 monthly visits from fabricating drug-seeking patients. Distinguishing drug …

Regional anesthesia for office procedures: part I. Head and neck surgeries

GA Salam - American Family Physician, 2004 - aafp.org
Although local anesthesia usually is used in surgical procedures, field or nerve blocks can
provide more effective anesthesia in some situations. In a field block, local anesthetic is …

Pharmacogenomics of codeine, morphine, and morphine-6-glucuronide: model-based analysis of the influence of CYP2D6 activity, UGT2B7 activity, renal impairment …

T Eissing, J Lippert, S Willmann - Molecular diagnosis & therapy, 2012 - Springer
Abstract Background and Objective: The analgesic effect of codeine depends on the
formation of the opioid metabolites morphine and morphine-6-glucuronide. Different factors …