Objective Most pituitary tumours occur sporadically without a genetically identifiable
germline abnormality, a small but increasing proportion present with a genetic defect that …

Genetic testing is becoming part of mainstream endocrinology. An increasing number of rare
and not-so-rare endocrine diseases have an identifiable genetic cause, either at the …

Purpose Inflammatory and infectious diseases of the pituitary gland (IIPD) are rare lesions
often misdiagnosed preoperatively. Immediate surgery is indicated especially in cases of …

The genetic landscape of corticotroph tumours of the pituitary gland has dramatically
changed over the last 10 years. Somatic changes in the USP8 gene account for the most …

The vast majority of pituitary neuroendocrine tumors (PitNETs) are benign and slow growing
with a low relapse rate over many years after surgical resection. However, about 40% are …

DNA damage repair pathways, including mismatch repair (MMR) genes, are prone to
carcinoma development in certain patients. The assessment of the MMR system is widely …

Scientific advances constantly improve our understanding of the mechanisms underlying
tumorigenesis, allowing us now to analyze cancer in a more precise manner and to identify …

Objective: Mutations in several genes have been associated with familial forms of pituitary
adenomas. Sporadic pituitary adenomas (ie with no family history or coexistent endocrine …

Background Pituitary tumors may cause compression of the optic chiasm, resulting in
decreased visual acuity. Therefore, decompression of the optic chiasm is a major goal of …

Les avancées scientifiques ne cessent d'améliorer notre compréhension des mécanismes
tumoraux, nous permettant désormais d'analyser les pathologies tumorales de manière de …