Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …