The roles of tumor-and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas

Y Mezawa, A Orimo - Cell and tissue research, 2016 - Springer
Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-
neoplastic mesenchymal cell compartment in various human tumors. These fibroblasts are …

Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues

M Li, N Xi, Y Wang, L Liu - Acta Pharmacologica Sinica, 2021 - nature.com
Mechanics are intrinsic properties which appears throughout the formation, development,
and aging processes of biological systems. Mechanics have been shown to play important …

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling

F Mousawi, H Peng, J Li, S Ponnambalam, S Roger… - Stem Cells, 2020 - academic.oup.com
In this study, we examined the Ca2+-permeable Piezo1 channel, a newly identified
mechanosensing ion channel, in human dental pulp-derived mesenchymal stem cells …

Collective curvature sensing and fluidity in three-dimensional multicellular systems

W Tang, A Das, AF Pegoraro, YL Han, J Huang… - Nature Physics, 2022 - nature.com
Collective cell migration is an essential process throughout the lives of multicellular
organisms, for example in embryonic development, wound healing and tumour metastasis …

Microtubules in 3D cell motility

BP Bouchet, A Akhmanova - Journal of cell science, 2017 - journals.biologists.com
ABSTRACT Three-dimensional (3D) cell motility underlies essential processes, such as
embryonic development, tissue repair and immune surveillance, and is involved in cancer …

[HTML][HTML] Store operated calcium entry in cell migration and cancer metastasis

AS Hammad, K Machaca - Cells, 2021 - mdpi.com
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis

M Wesseling, TR Sakkers, SCA De Jager… - Vascular …, 2018 - Elsevier
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a
pathologic feature in the progression of disease or as a response to injury. Endothelial-to …

[HTML][HTML] Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Carcinogenesis and reactive oxygen species signaling: Interaction of the NADPH oxidase NOX1–5 and superoxide dismutase 1–3 signal transduction pathways

A Parascandolo, MO Laukkanen - Antioxidants & redox signaling, 2019 - liebertpub.com
Abstract Significance: Reduction/oxidation (redox) balance could be defined as an even
distribution of reduction and oxidation complementary processes and their reaction end …

Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

ER Summerbell, JK Mouw, JSK Bell, CM Knippler… - Science …, 2020 - science.org
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse,
yet remains largely underexplored in invasion and metastasis. Here, we investigated …