A guide to chemokines and their receptors

CE Hughes, RJB Nibbs - The FEBS journal, 2018 - Wiley Online Library
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

[HTML][HTML] Host-directed therapies for bacterial and viral infections

SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Targeting cytokines to treat asthma and chronic obstructive pulmonary disease

PJ Barnes - Nature Reviews Immunology, 2018 - nature.com
Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy

A Shamsi, T Mohammad, S Anwar, MF AlAjmi… - Bioscience …, 2020 - portlandpress.com
Due to the lack of efficient therapeutic options and clinical trial limitations, the FDA-approved
drugs can be a good choice to handle Coronavirus disease (COVID-19). Many reports have …

Virus–receptor interactions: the key to cellular invasion

MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

Mass cytometry imaging for the study of human diseases—applications and data analysis strategies

H Baharlou, NP Canete, AL Cunningham… - Frontiers in …, 2019 - frontiersin.org
High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

Clinical significance of chemokine receptor antagonists

M Miao, E De Clercq, G Li - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …

CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent

J Wang, BA Tannous, MC Poznansky, H Chen - Pharmacological research, 2020 - Elsevier
Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …

[PDF][PDF] Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7

K Jaeger, S Bruenle, T Weinert, W Guba, J Muehle… - Cell, 2019 - cell.com
The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic
trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to lymph node …

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5

G Nishikawa, K Kawada, J Nakagawa, K Toda… - Cell death & …, 2019 - nature.com
Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors,
where they serve as critical components of the tumor microenvironment by secreting growth …