Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Neutrophil extracellular traps: villains and targets in arterial, venous, and cancer-associated thrombosis

C Thålin, Y Hisada, S Lundström… - … , and vascular biology, 2019 - Am Heart Assoc
Recent studies have demonstrated a role of neutrophils in both venous and arterial
thrombosis. A key prothrombotic feature of neutrophils is their ability to release web-like …

The neutrophil–lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials

NH Adamstein, JG MacFadyen, LM Rose… - European heart …, 2021 - academic.oup.com
Aims The neutrophil–lymphocyte ratio (NLR) is a readily available inflammatory biomarker
that may associate with atherosclerosis and predict cardiovascular (CV) events. The aims of …

Update on neutrophil function in severe inflammation

E Mortaz, SD Alipoor, IM Adcock, S Mumby… - Frontiers in …, 2018 - frontiersin.org
Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …

Myeloperoxidase–A bridge linking inflammation and oxidative stress with cardiovascular disease

G Ndrepepa - Clinica chimica acta, 2019 - Elsevier
Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

Vascular Behçet syndrome: from pathogenesis to treatment

A Bettiol, F Alibaz-Oner, H Direskeneli… - Nature Reviews …, 2023 - nature.com
Behçet syndrome is a rare, chronic inflammatory disease of unknown aetiopathogenesis,
most commonly presenting with mucocutaneous and ocular manifestations. Vascular …

More friend than foe: the emerging role of neutrophils in tissue repair

M Peiseler, P Kubes - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …

[HTML][HTML] Understanding the role of neutrophils in acute respiratory distress syndrome

SC Yang, YF Tsai, YL Pan, TL Hwang - Biomedical Journal, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high
mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to …

Neutrophil extracellular traps in atherosclerosis and atherothrombosis

Y Döring, O Soehnlein, C Weber - Circulation research, 2017 - Am Heart Assoc
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex
structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These …

Targeted therapy of atherosclerosis by a broad-spectrum reactive oxygen species scavenging nanoparticle with intrinsic anti-inflammatory activity

Y Wang, L Li, W Zhao, Y Dou, H An, H Tao, X Xu… - ACS …, 2018 - ACS Publications
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative
therapy has been considered promising for the treatment of atherosclerosis in view of a …