Traumatic brain injury: a potential cause of violent crime?

WH Williams, P Chitsabesan, S Fazel… - The Lancet …, 2018 - thelancet.com
Traumatic brain injury (TBI) is the biggest cause of death and disability in children and
young people. TBI compromises important neurological functions for self-regulation and …

[HTML][HTML] Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI

X Ge, M Guo, T Hu, W Li, S Huang, Z Yin, Y Li, F Chen… - Molecular Therapy, 2020 - cell.com
Repetitive mild traumatic brain injury (rmTBI) is considered to be an important risk factor for
long-term neurodegenerative disorders such as Alzheimer's disease, which is characterized …

[HTML][HTML] Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

QS Li, YJ Jia - Neural Regeneration Research, 2023 - journals.lww.com
Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-
dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic …

[HTML][HTML] The curing coma campaign: framing initial scientific challenges—proceedings of the first curing coma campaign scientific advisory council meeting

JJ Provencio, JC Hemphill, J Claassen, BL Edlow… - Neurocritical care, 2020 - Springer
Coma and disordered consciousness are common manifestations of acute neurological
conditions and are among the most pervasive and challenging aspects of treatment in …

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

XS Zhang, Y Lu, W Li, T Tao, L Peng… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Oxidative stress and neuronal apoptosis play key roles in
traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic …

Definition and epidemiology of mild traumatic brain injury

C Lefevre-Dognin, M Cogné, V Perdrieau, A Granger… - Neurochirurgie, 2021 - Elsevier
Background/objectives The definition of mild traumatic brain injury (mTBI), also known as
concussion, has been a matter of controversy, which makes comparison between studies …

[HTML][HTML] Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis

W Zhang, J Hong, H Zhang, W Zheng, Y Yang - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
In this study, we investigated the mechanisms through which astrocyte-derived exosomes
(AS-Exos) alleviate traumatic brain injury (TBI)-induced neuronal defects in TBI model rats …

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

IRAR Helmrich, E Czeiter, K Amrein, A Büki… - The Lancet …, 2022 - thelancet.com
Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and astrocyte-mediated neuroinflammatory responses

J Wang, Y Hou, L Zhang, M Liu, J Zhao, Z Zhang… - Molecular …, 2021 - Springer
Traumatic brain injury (TBI), which leads to high mortality and morbidity, is a prominent
public health problem worldwide. Neuroinflammation involving microglia and astrocyte …