Reactive oxygen species scavenging functional hydrogel delivers procyanidins for the treatment of traumatic brain injury in mice

X Huang, Y Ye, J Zhang, X Zhang, H Ma… - … Applied Materials & …, 2022 - ACS Publications
Traumatic brain injury (TBI) is accompanied by the overload of reactive oxygen species
(ROS), which can result in secondary brain injury. Although procyanidins (PCs) have a …

[HTML][HTML] Recommendations for the design and implementation of virtual reality for acquired brain injury rehabilitation: systematic review

S Brassel, E Power, A Campbell, M Brunner… - Journal of medical …, 2021 - jmir.org
Background Virtual reality (VR) is increasingly being used for the assessment and treatment
of impairments arising from acquired brain injuries (ABIs) due to perceived benefits over …

[HTML][HTML] Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain …

TJ Krämer, N Hack, TJ Brühl, L Menzel… - Journal of …, 2019 - Springer
Background Traumatic brain injury (TBI) is a major cause of death and disability. T cells
were shown to infiltrate the brain during the first days after injury and to exacerbate tissue …

Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials

KA Lawati, S Sharif, SA Maqbali, HA Rimawi… - Intensive care …, 2021 - Springer
Purpose With the publication of a large randomized-controlled trial (RCT) suggesting that
tranexamic acid (TXA) may improve head-injury-related deaths, we aimed to determine the …

[HTML][HTML] Measuring consciousness in the intensive care unit

BL Edlow, M Fecchio, YG Bodien, A Comanducci… - Neurocritical Care, 2023 - Springer
Early reemergence of consciousness predicts long-term functional recovery for patients with
severe brain injury. However, tools to reliably detect consciousness in the intensive care unit …

[HTML][HTML] TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications

J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …

Systemic inflammation persists the first year after mild traumatic brain injury: results from the prospective trondheim mild traumatic brain injury study

V Chaban, GJB Clarke, T Skandsen, R Islam… - Journal of …, 2020 - liebertpub.com
Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and
successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate …

Prognosis in moderate and severe traumatic brain injury: a systematic review of contemporary models and validation studies

SA Dijkland, KA Foks, S Polinder, DWJ Dippel… - Journal of …, 2020 - liebertpub.com
Outcome prognostication in traumatic brain injury (TBI) is important but challenging due to
heterogeneity of the disease. The aim of this systematic review is to present the current state …

Cognitive rehabilitation in patients with traumatic brain injury: A narrative review on the emerging use of virtual reality

MG Maggio, R De Luca, F Molonia, B Porcari… - Journal of Clinical …, 2019 - Elsevier
Traumatic brain injury (TBI) is a clinical condition characterized by brain damage due to an
external, rapid and violent force. TBI causes attention, memory, affectivity, behaviour …