Feasibility of individualised severe traumatic brain injury management using an automated assessment of optimal cerebral perfusion pressure: the COGiTATE phase II …

E Beqiri, P Smielewski, C Robba, M Czosnyka… - BMJ open, 2019 - bmjopen.bmj.com
Introduction Individualising therapy is an important challenge for intensive care of patients
with severe traumatic brain injury (TBI). Targeting a cerebral perfusion pressure (CPP) …

[HTML][HTML] Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes

XL Liu, DD Sun, MT Zheng, XT Li, HH Niu… - Neural regeneration …, 2023 - journals.lww.com
Neuroinflammation and the NACHT, LRR, and PYD domains-containing protein 3
inflammasome play crucial roles in secondary tissue damage following an initial insult in …

Association of prehospital plasma with survival in patients with traumatic brain injury: a secondary analysis of the PAMPer cluster randomized clinical trial

DS Gruen, FX Guyette, JB Brown… - JAMA Network …, 2020 - jamanetwork.com
Importance Prehospital plasma administration improves survival in injured patients at risk for
hemorrhagic shock and transported by air ambulance. Traumatic brain injury (TBI) is a …

[HTML][HTML] Post-concussion symptoms in complicated vs. uncomplicated mild traumatic brain injury patients at three and six months post-injury: results from the CENTER …

DC Voormolen, JA Haagsma, S Polinder… - Journal of clinical …, 2019 - mdpi.com
The aim of this study was to assess the occurrence of post-concussion symptoms and post-
concussion syndrome (PCS) in a large cohort of patients after complicated and …

Cognitive rehabilitation in patients with traumatic brain injury: A narrative review on the emerging use of virtual reality

MG Maggio, R De Luca, F Molonia, B Porcari… - Journal of Clinical …, 2019 - Elsevier
Traumatic brain injury (TBI) is a clinical condition characterized by brain damage due to an
external, rapid and violent force. TBI causes attention, memory, affectivity, behaviour …

[HTML][HTML] Cerebral microvascular injury: a potentially treatable endophenotype of traumatic brain injury-induced neurodegeneration

DK Sandsmark, A Bashir, CL Wellington… - Neuron, 2019 - cell.com
Traumatic brain injury (TBI) is one the most common human afflictions, contributing to long-
term disability in survivors. Emerging data indicate that functional improvement or …

Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury

L Wilson, L Horton, K Kunzmann… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective Cognitive impairment is a key cause of disability after traumatic brain injury (TBI)
but relationships with overall functioning in daily life are often modest. The aim is to examine …

[HTML][HTML] Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

T Li, W Zhang, E Hu, Z Sun, P Li, Z Yu, X Zhu… - Computational and …, 2021 - Elsevier
Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability
worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential …

Astrocytes in functional recovery following central nervous system injuries

QM Alhadidi, GA Bahader, O Arvola… - The Journal of …, 2023 - Wiley Online Library
Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

[HTML][HTML] Near-infrared spectroscopy (NIRS) in traumatic brain injury (TBI)

M Roldán, PA Kyriacou - Sensors, 2021 - mdpi.com
Traumatic brain injury (TBI) occurs when a sudden trauma causes damage to the brain. TBI
can result when the head suddenly and violently impacts an object or when an object …