Airway surface liquid (ASL) lines the conducting airways of the respiratory tract. We collected
small samples of this liquid from the lower tracheae of anesthetized C57BL/6 mice and …

Epithelial ion transport disorders, including cystic fibrosis, adversely affect male reproductive
function by nonobstructive mechanisms and by obstruction of the distal duct. Continuous cell …

cAMP-elevating agents such as forskolin and vasoactive intestinal peptide induce liquid
secretion by tracheobronchial submucosal glands. This pathway is thought to be CFTR …

Nasal potential difference (PD) measurements have been used to demonstrate defective
CFTR function in cystic fibrosis (CF) and to evaluate potential CF therapies. We used the …

The Calu‐3 human cell line exhibits features of submucosal gland serous cells and secretes
HCO3−. The aim of this study was to identify the HCO3− transporters present in these cells …

This study evaluated the pulmonary pathophysiology of pigs with transgenic CFTR “gut-
corrected” cystic fibrosis (CF). Four sows produced 18 piglets of which 11 were stillborn, with …

There is strong evidence that abnormal airway ion transport is the primary defect that
initiates the pathophysiology of lung disease in cystic fibrosis (CF). To examine the …

Transepithelial bicarbonate secretion by human airway submucosal glands and surface
epithelial cells is crucial to maintain the pH-sensitive innate defence mechanisms of the …

Mast cell activation requires Cl− flux, which maintains the driving force for entry of
extracellular calcium and initiates release of mediators such as histamine. However …

Since anion secretion inhibitors reproduce important aspects of cystic fibrosis (CF) lung
disease, the effects of these antagonists on airway mucus morphology were assessed in …