A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …
which are common and integral feature of a variety of natural products and pharmaceutical …
Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, Spodoptera littoralis (Boisduval)
Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1 H-
pyrrol-2-yl) thio] acetic acids 2a-c, 2-[(2-hydroxyethyl)-thio]-5-aryl-1 H-pyrrole-3-carbonitriles …
pyrrol-2-yl) thio] acetic acids 2a-c, 2-[(2-hydroxyethyl)-thio]-5-aryl-1 H-pyrrole-3-carbonitriles …
An insight on synthetic and medicinal aspects of pyrazolo [1, 5-a] pyrimidine scaffold
S Cherukupalli, R Karpoormath… - European journal of …, 2017 - Elsevier
Abstract Pyrazolo [1, 5-a] pyrimidine scaffold is one of the privileged hetrocycles in drug
discovery. Its application as a buliding block for developing drug-like candidates has …
discovery. Its application as a buliding block for developing drug-like candidates has …
Recent advances in the chemistry and biology of benzothiazoles
Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five‐
membered thiazole ring. This moiety has attracted considerable attention because of its …
membered thiazole ring. This moiety has attracted considerable attention because of its …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
Based on the structural study of previously known CDK2 inhibitors, a new series of pyrazolo
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …
Anti-cancer pyrimidines in diverse scaffolds: a review of patent literature
Pyrimidine ring is the building unit of DNA and RNA and thus pyrimidine based chemical
architectures exhibit diverse pharmacological activities. Among the reported medicinal …
architectures exhibit diverse pharmacological activities. Among the reported medicinal …
2-substituted benzothiazoles as antiproliferative agents: Novel insights on structure-activity relationships
Given the wide spectrum of biological activities, benzothiazoles represent privileged
scaffolds in medicinal chemistry, useful in drug discovery programs to modulate biological …
scaffolds in medicinal chemistry, useful in drug discovery programs to modulate biological …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Importance of fluorine in benzazole compounds
Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …