Robust and efficient processes are needed to establish scientific confidence in new
approach methodologies (NAMs) if they are to be considered for regulatory applications …

Highlights•Artificial Intelligence (AI) has transformed many areas such as speech and image
recognition, but not yet drug discovery.•Approaches to AI in drug discovery need to take in …

Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Since its discovery in 2004, graphene is increasingly applied in various fields owing to its
unique properties. Graphene application in the biomedical domain is promising and …

Simple Summary We review the value of large animal models for improving the translation of
biomedical research for human application, focusing primarily on sheep. Abstract An …

Zinc-finger nuclease (ZFN)-based in vivo genome editing is a novel treatment that can
potentially provide lifelong protein replacement with single intravenous administration …

Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded
with therapeutic molecules and engineered for retention by specific tissues. However …

The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in
part is associated with gelatinase from neutrophils. This protein shows a high degree of …

Neurodegenerative diseases are fatal disorders of the central nervous system (CNS) which
currently lack effective treatments. The application of mesenchymal stem cells (MSCs) …