Clinical translation of advanced colonic drug delivery technologies

A Awad, CM Madla, LE McCoubrey, F Ferraro… - Advanced drug delivery …, 2022 - Elsevier
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

[HTML][HTML] Gut microbiota metabolites in major depressive disorder—Deep insights into their pathophysiological role and potential translational applications

MA Ortega, MA Alvarez-Mon, C García-Montero… - Metabolites, 2022 - mdpi.com
The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

[HTML][HTML] Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour

SF Henriques, DB Dhakan, L Serra… - Nature …, 2020 - nature.com
The impact of commensal bacteria on the host arises from complex microbial-diet-host
interactions. Mapping metabolic interactions in gut microbial communities is therefore key to …

[HTML][HTML] Gut microbiome modulates Drosophila aggression through octopamine signaling

Y Jia, S Jin, K Hu, L Geng, C Han, R Kang… - Nature …, 2021 - nature.com
Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we
report that gut microbiome modulates aggressive behaviors in Drosophila. We found that …

[HTML][HTML] Impact of cocoa flavanols on human health

MÁ Martin, S Ramos - Food and Chemical Toxicology, 2021 - Elsevier
Cocoa is a source of flavanols, and these phenolic compounds exert beneficial effects on
health and aging, and reduce the risk of suffering chronic diseases (cardiovascular …

[HTML][HTML] Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human

H Schellekens, C Torres-Fuentes, M van de Wouw… - …, 2021 - thelancet.com
Background The human gut microbiota has emerged as a key factor in the development of
obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study …

Harnessing machine learning for development of microbiome therapeutics

LE McCoubrey, M Elbadawi, M Orlu, S Gaisford… - Gut …, 2021 - Taylor & Francis
The last twenty years of seminal microbiome research has uncovered microbiota's intrinsic
relationship with human health. Studies elucidating the relationship between an unbalanced …

Identifying microbiome-mediated behaviour in wild vertebrates

GL Davidson, A Raulo, SCL Knowles - Trends in Ecology & Evolution, 2020 - cell.com
Recent research in laboratory animals has illuminated how the vertebrate gut microbiome
can have diverse and powerful effects on the brain and behaviour. However, the ecological …

Effect of cocoa and cocoa products on cognitive performance in young adults

MA Martín, L Goya, S de Pascual-Teresa - Nutrients, 2020 - mdpi.com
Increasing evidence support a beneficial role of cocoa and cocoa products on human
cognition, particularly in aging populations and patients at risk. However, thorough reviews …

[HTML][HTML] Diet induces parallel changes to the gut microbiota and problem solving performance in a wild bird

GL Davidson, N Wiley, AC Cooke, CN Johnson… - Scientific reports, 2020 - nature.com
The microbial community in the gut is influenced by environmental factors, especially diet,
which can moderate host behaviour through the microbiome-gut-brain axis. However, the …