An overview of PDE4 inhibitors in clinical trials: 2010 to early 2022
L Crocetti, G Floresta, A Cilibrizzi, MP Giovannoni - Molecules, 2022 - mdpi.com
Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …
treatment of inflammation-based diseases. Several scientific advancements, by both …
[HTML][HTML] Puerarin: a potential natural neuroprotective agent for neurological disorders
X Liu, R Huang, J Wan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …
TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis
V Majumder, JM Gregory, MA Barria, A Green, S Pal - BMC neurology, 2018 - Springer
Background Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are
incurable, progressive and fatal neurodegenerative diseases with patients variably affected …
incurable, progressive and fatal neurodegenerative diseases with patients variably affected …
[HTML][HTML] Efficient machine learning approach for volunteer eye-blink detection in real-time using webcam
PA de Lima Medeiros, GVS da Silva… - Expert Systems with …, 2022 - Elsevier
The progressive diminishment of motor capacities due to Amyotrophic Lateral Sclerosis
(ALS) causes a severe communication deficit. The development of Alternative …
(ALS) causes a severe communication deficit. The development of Alternative …
Multi-sided platform and data-driven care research: A longitudinal case study on business model innovation for improving care in complex neurological diseases
Multi-sided platforms in healthcare often focus their business model on standardizing care
for wide-spread, chronic diseases. However, there is a lack of knowledge surrounding …
for wide-spread, chronic diseases. However, there is a lack of knowledge surrounding …
Emerging novel approaches for the enhanced delivery of natural products for the management of neurodegenerative diseases
Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington disease, amyotrophic lateral sclerosis, and prion disease affect any part of the …
Huntington disease, amyotrophic lateral sclerosis, and prion disease affect any part of the …
Cannabis for the treatment of amyotrophic lateral sclerosis: What is the patients' view?
C Lacroix, R Guilhaumou, J Micallef, G Bruneteau… - Revue …, 2023 - Elsevier
Cannabis may have therapeutic benefits to relieve symptoms of amyotrophic lateral
sclerosis (ALS) thanks to its pleiotropic pharmacological activity. This study is the first to …
sclerosis (ALS) thanks to its pleiotropic pharmacological activity. This study is the first to …
Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases
Neurodegenerative diseases are the most widely affected disease condition in an aging
population. The treatment available reduces the elevated manifestations but is ineffective …
population. The treatment available reduces the elevated manifestations but is ineffective …
Multidisciplinary care in amyotrophic lateral sclerosis: a systematic review and meta-analysis
FEO de Almeida, AK do Carmo Santana… - Neurological …, 2021 - Springer
Multidisciplinary care (MDC) has been the most recommended approach for symptom
management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its …
management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its …
Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling
B Arjmand, S Kokabi Hamidpour, Z Rabbani… - Frontiers in …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis is a pernicious neurodegenerative disorder that is associated
with the progressive degeneration of motor neurons, the disruption of impulse transmission …
with the progressive degeneration of motor neurons, the disruption of impulse transmission …