Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

Matrix metalloproteinases (MMPs) are zincdependent endopeptidases that were first
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …

Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …