Next-generation sequencing technologies: An overview

T Hu, N Chitnis, D Monos, A Dinh - Human Immunology, 2021 - Elsevier
Since the days of Sanger sequencing, next-generation sequencing technologies have
significantly evolved to provide increased data output, efficiencies, and applications. These …

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers

G Federici, S Soddu - Journal of Experimental & Clinical Cancer Research, 2020 - Springer
The promising expectations about personalized medicine have opened the path to routine
large-scale sequencing and increased the importance of genetic counseling for hereditary …

Fungal–metal interactions: A review of toxicity and homeostasis

JR Robinson, OS Isikhuemhen, FN Anike - Journal of Fungi, 2021 - mdpi.com
Metal nanoparticles used as antifungals have increased the occurrence of fungal–metal
interactions. However, there is a lack of knowledge about how these interactions cause …

Genome interpretation using in silico predictors of variant impact

P Katsonis, K Wilhelm, A Williams, O Lichtarge - Human genetics, 2022 - Springer
Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

[HTML][HTML] Pharmacogenomics in treatment of depression and psychosis: an update

M Jukic, F Milosavljević, E Molden… - Trends in …, 2022 - cell.com
Genetic factors can, to a certain extent, successfully predict the therapeutic effects,
metabolism, and adverse reactions of drugs. This research field, pharmacogenomics, is well …

Omics technologies in allergy and asthma research: An EAACI position paper

U Radzikowska, K Baerenfaller, JA Cornejo‐Garcia… - Allergy, 2022 - Wiley Online Library
Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

Next generation sequencing based forward genetic approaches for identification and mapping of causal mutations in crop plants: A comprehensive review

PK Sahu, R Sao, S Mondal, G Vishwakarma, SK Gupta… - Plants, 2020 - mdpi.com
The recent advancements in forward genetics have expanded the applications of mutation
techniques in advanced genetics and genomics, ahead of direct use in breeding programs …

implementing whole genome sequencing (WGS) in clinical practice: advantages, challenges, and future perspectives

P Brlek, L Bulić, M Bračić, P Projić, V Škaro, N Shah… - Cells, 2024 - mdpi.com
The integration of whole genome sequencing (WGS) into all aspects of modern medicine
represents the next step in the evolution of healthcare. Using this technology, scientists and …

Computational approaches for modeling and structural design of biological systems: A comprehensive review

E Gayathiri, P Prakash, P Kumaravel… - Progress in Biophysics …, 2023 - Elsevier
The convergence of biology and computational science has ushered in a revolutionary era,
revolutionizing our understanding of biological systems and providing novel solutions to …

Trimming and validation of Illumina short reads using trimmomatic, trinity assembly, and assessment of RNA-seq data

SO Sewe, G Silva, P Sicat, SE Seal… - … : Methods and protocols, 2022 - Springer
Next-generation sequencing (NGS) technologies can generate billions of reads in a single
sequencing run. However, with such high-throughput comes quality issues which have to be …