The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in
sight. Complications of DM2 involve a myriad of comorbidities including the serious …

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been
considered to be relatively 'passive'cells which are responsible for the synthesis and …

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and
Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev. 00032.2002.—Cutaneous …

Macrophages are mononuclear phagocytes established during embryogenesis and derived
from the yolk sac or the fetal liver but also recruited from the blood and bone marrow under …

Angiogenesis is critical to wound repair. Newly formed blood vessels participate in
provisional granulation tissue formation and provide nutrition and oxygen to growing tissues …

Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs)
communicate with organ systems to adjust immune response, provide signals for …

The adverse long‐term effects of diabetes mellitus have been well described and involve
many organ systems. While diabetes management has largely focused on control of …

The use of platelet-rich plasma (PRP) in bone reconstruction therapy was introduced in the
late 1990s. Since then, many scientists and clinicians have employed it in orthopaedic and …

Macrophages are primarily known as phagocytic innate immune cells, but are, in fact, highly
dynamic multi-taskers that interact with many different tissue types and have regulatory roles …