[HTML][HTML] Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: beginning a new era in cancer theragnostic
Abstract The American Cancer Society estimated around 61,090 new cases of leukemia
were diagnosed, and around 23,660 people died from this disease in the United States …
were diagnosed, and around 23,660 people died from this disease in the United States …
Sniping cancer stem cells with nanomaterials
WD Wang, YY Guo, ZL Yang, GL Su, ZJ Sun - ACS nano, 2023 - ACS Publications
Cancer stem cells (CSCs) drive tumor initiation, progression, and therapeutic resistance due
to their self-renewal and differentiation capabilities. Despite encouraging progress in cancer …
to their self-renewal and differentiation capabilities. Despite encouraging progress in cancer …
Metabolic remodeling in cancer and senescence and its therapeutic implications
Y Kim, Y Jang, MS Kim, C Kang - Trends in Endocrinology & Metabolism, 2024 - cell.com
Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …
Proteasome inhibitors as anticancer agents
G Gazzaroli, A Angeli, A Giacomini… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The therapeutic targeting of the ubiquitin-proteasome pathway (UPP) through
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …
[HTML][HTML] Diagnostic and therapeutic potential of protease inhibition
N Ćwilichowska, KW Świderska, A Dobrzyń… - Molecular Aspects of …, 2022 - Elsevier
Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …
control virtually all biological processes. Our understanding of protease function has …
HSP90β Impedes STUB1‐Induced Ubiquitination of YTHDF2 to Drive Sorafenib Resistance in Hepatocellular Carcinoma
Y Liao, Y Liu, C Yu, Q Lei, J Cheng, W Kong… - Advanced …, 2023 - Wiley Online Library
Abstract YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m6A)
reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 …
reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 …
RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons
Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during
their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA …
their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA …
TCH-165 attenuates cardiac ischaemia/reperfusion injury by balancing mitochondrial dynamics via increasing proteasome activity
J Gao, HX Su, PB Li, KN Shi, HH Li - European Journal of Pharmacology, 2023 - Elsevier
The proteasome is the main complex responsible for maintaining intracellular protein
homeostasis, impairment of which is associated with cardiac ischaemia/reperfusion (I/R) …
homeostasis, impairment of which is associated with cardiac ischaemia/reperfusion (I/R) …
Role of UBE2C in brain cancer invasion and dissemination
S Domentean, E Paisana, R Cascão… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults
and are invariably associated with a dismal outcome. These highly malignant tumors share …
and are invariably associated with a dismal outcome. These highly malignant tumors share …