Heart failure with preserved ejection fraction (HFpEF) has been recognized as the greatest
single unmet need in cardiovascular medicine. Indeed, the morbi-mortality of HFpEF is high …

The review summarises the data of the last 50 years on the effectiveness of the amino acid L-
arginine in therapeutic practice in conditions accompanied by different-origin hypoxia. The …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Background & aims Nitric oxide bioactivity (NO) from endothelial NO synthase (eNOS)
importantly contributes to the maintenance of vascular homeostasis, and reduced eNOS …

Ethnopharmacological relevance Smilax china L., an extensively used traditional Chinese
medicine, is known as Baqia in China. It has been used to treat various inflammatory …

Circulating blood platelets are controlled by stimulatory and inhibitory factors, and a tightly
regulated equilibrium between these two opposing processes is essential for normal platelet …

Drug‐coated balloons (DCB) intervention is an important approach for the treatment of
atherosclerosis (AS). However, this therapeutic approach has the drawbacks of poor drug …

Nitric oxide (NO) is a well-known gaseous mediator that maintains vascular homeostasis.
Extensive evidence supports that a hallmark of endothelial dysfunction, which leads to …

Perivascular adipose tissue (PVAT) is a special type of ectopic fat depot that adheres to most
vasculatures. PVAT has been shown to exert anticontractile effects on the blood vessels and …

Beyond their established role as oxygen carriers, red blood cells have recently been found
to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant …