Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

H Cai, L Huang, M Wang, R Liu, J Qiu, Y Qin, X Yao… - Food & Function, 2024 - pubs.rsc.org
Pterostilbene (PTE), a natural stilbene found in blueberries and several varieties of grapes,
has several pharmacological activities, including anti-inflammatory and antioxidative …

MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression

X Si, Q Chen, J Zhang, W Zhou, L Chen, J Chen… - Life Sciences, 2022 - Elsevier
Aims Phenotypic switching of vascular smooth muscle cells (VSMCs) is essential for the
formation of abdominal aortic aneurysms (AAAs). MicroRNA-23b (miR-23b) has recently …

Effects of spermidine on gut microbiota modulation in experimental abdominal aortic aneurysm mice

S Liu, Y Liu, J Zhao, P Yang, W Wang, M Liao - Nutrients, 2022 - mdpi.com
Accumulating evidence in recent years has demonstrated the important role of gut
microbiota in maintaining cardiovascular function. However, their functions in abdominal …

Spermidine suppresses development of experimental abdominal aortic aneurysms

S Liu, T Huang, R Liu, H Cai, B Pan… - Journal of the …, 2020 - Am Heart Assoc
Background The protective effects of polyamines on cardiovascular disease have been
demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in …

Imaging predictive factors of abdominal aortic aneurysm growth

P Nana, K Spanos, K Dakis, A Brodis… - Journal of Clinical …, 2021 - mdpi.com
Background: Variable imaging methods may add important information about abdominal
aortic aneurysm (AAA) progression. The aim of this study is to assess available literature …

D-dimer is a diagnostic biomarker of abdominal aortic aneurysm in patients with peripheral artery disease

H Cai, B Pan, J Xu, S Liu, L Wang, K Wu… - Frontiers in …, 2022 - frontiersin.org
Background Etiology and risk factors of peripheral artery disease (PAD) include age,
smoking, and hypertension, etc., which are shared by an abdominal aortic aneurysm (AAA) …

Identification of abdominal aortic aneurysm subtypes based on mechanosensitive genes

C Sheng, Q Zeng, W Huang, M Liao, P Yang - Plos one, 2024 - journals.plos.org
Background Rupture of abdominal aortic aneurysm (rAAA) is a fatal event in the elderly.
Elevated blood pressure and weakening of vessel wall strength are major risk factors for this …

Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population

T Huang, S Liu, J Huang, B Xu, Y Bai… - BMC cardiovascular …, 2019 - Springer
Background Several studies on the growth rates of abdominal aortic aneurysm (AAA) in
Chinese population have been conducted; however, this issue remains unclear. The aim of …

[HTML][HTML] Inhibition of phosphatidylinositol 3-kinase γ by IPI-549 attenuates abdominal aortic aneurysm formation in mice

R Liu, J Huang, Y Ge, S Liu, T Huang, H Cai… - European Journal of …, 2020 - Elsevier
Objective The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signalling
pathway plays a pivotal role in abdominal aortic aneurysm (AAA). However, systemic …

Attenuation of smooth muscle cell phenotypic switching by angiotensin 1-7 protects against thoracic aortic aneurysm

AS Jadli, NN Ballasy, KP Gomes, CDA Mackay… - International Journal of …, 2022 - mdpi.com
Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic
wall, leading to reduced biomechanical support with risk of aortic dissection and rupture …