Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …

Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …

Background Accumulating evidence suggests that circular RNAs (circRNAs) are important
participants in cancer progression. However, the biological processes and underlying …

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …

Purpose: Cancer-associated fibroblasts have emerged to be highly heterogenous and can
play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression …

Pancreatic ductal adenocarcinoma (PDAC) strongly resists standard therapies since KRAS-
mutated cancer cells harbor endogenous resistance toward chemotherapy-induced …

Simple Summary The extracellular matrix (ECM) has emerged as a critical part of the tumor
microenvironment. This glycoprotein-and proteoglycan-rich part of the tumor serves as a …

Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) features high recurrence rates and intensified
lethality, accompanied by stiffening of the extracellular matrix (ECM) microenvironment …