Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Heme oxgenase-1, a cardinal modulator of regulated cell death and inflammation

SW Ryter - Cells, 2021 - mdpi.com
Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Necroptosis: a novel pathway in neuroinflammation

Z Yu, N Jiang, W Su, Y Zhuo - Frontiers in pharmacology, 2021 - frontiersin.org
Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …

Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine

X Wang, P Hua, C He, M Chen - Acta Pharmaceutica Sinica B, 2022 - Elsevier
As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …

Necroptosis in immuno-oncology and cancer immunotherapy

J Sprooten, P De Wijngaert, I Vanmeerbeek, S Martin… - Cells, 2020 - mdpi.com
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Insight into crosstalk between ferroptosis and necroptosis: novel therapeutics in ischemic stroke

Y Zhou, J Liao, Z Mei, X Liu, J Ge - Oxidative Medicine and …, 2021 - Wiley Online Library
Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Y Zhou, A Shao, Y Yao, S Tu, Y Deng… - Cell Communication and …, 2020 - Springer
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …

Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer: a review

JY Jang, E Im, ND Kim - International journal of molecular sciences, 2022 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene), a polyphenol found in grapes, red wine,
peanuts, and apples, has been reported to exhibit a wide range of biological and …

[HTML][HTML] Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver

S Li, R Liu, S Xia, G Wei, M Ishfaq, Y Zhang… - … and environmental safety, 2022 - Elsevier
This study set out to assess the mitigative effects of curcumin on AFB1-induced necroptosis
and inflammation in chicken liver. Ninety-six one-day-old AA broiler chickens were …

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

WT Yan, S Lu, YD Yang, WY Ning, Y Cai… - Neural regeneration …, 2021 - journals.lww.com
There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated
by cell signaling pathways, while necrosis has until recently been considered a passive …