Abstract Development of a cancer is a multistep process and six major hallmarks of cancer
that are known to control malignant transformation have been described. Anticancer drug …

In order to detect biomolecules, different approaches using for instance biological,
spectroscopic or imaging techniques are established. Due to the broad variety of these …

BACKGROUND: Accumulating evidence suggests that DNA methylation markers could
serve as sensitive and specific cancer biomarkers. OBJECTIVE: To determine whether a …

Methylation is an important epigenetic DNA modification that governs gene expression. The
genomic level of methylated DNA and its derivatives may serve as important indicators for …

Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …

Purpose: Gastric cancer is a curable disease if diagnosed at early stage. However, most
cases are diagnosed at advanced stage because of the lack of screening programs …

BACKGROUND: Esophageal squamous cell carcinomas (ESCCs) tend to have multiple
primary lesions, and it is believed that they arise from background mucosae with …

DNA methylation as part of the epigenetic gene-silencing complex is a universal occurring
change in lung cancer. Numerous studies investigated methylation of specific genes in …

This study aimed to clarify genetic and epigenetic alterations that occur during lung
carcinogenesis and to design perspective sets of newly identified biomarkers. The original …

Methylation of cytosines in cytosine–guanine (CpG) dinucleotides is one of the most
important epigenetic alterations in animals. The presence of methylcytosine in the promoter …