The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

The general description of kinins refers to these peptides as molecules involved in vascular
tone regulation and inflammation. Nevertheless, in the last years a series of evidences has …

Background: The blood–brain barrier (BBB) describes the brain's highly specialized
capillaries, which form a dynamic interface that maintains central nervous system (CNS) …

Chemokines may play a role in leukocyte migration across the blood-brain barrier (BBB)
during neuroinflammation and other neuropathological processes, such as epilepsy. We …

The importance of cholinergic mechanisms for epilepsy was already hinted at by
neurologists at the turn of the nineteenth century (Langley, 1901; Langley and Kato, 1915) …

Neuroprotection is a desirable process in many neurological disorders, yet complex
mechanisms involved in this field are not completely understood. The pilocarpine epilepsy …

The kallikrein-kinin system (KKS) is an intricate endogenous pathway involved in several
physiological and pathological cascades in the brain. Due to the pathological effects of …

Statins may act on inflammatory responses, decreasing oxidative stress and also reducing
brain inflammation in several brain disorders. Epileptogenesis is a process in which a …