Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer
through plasmids plays a major role. The identification of plasmid characteristics and their …

Coevolution between bacteriophages (phages) and their bacterial hosts occurs through
changes in resistance and counter-resistance mechanisms. To assess phage–host …

The ability to artificially control transcription is essential both to the study of gene function
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …

Integrons are genetic elements involved in bacterial adaptation which capture, shuffle and
express genes encoding adaptive functions embedded in cassettes. These events are …

Cell-intrinsic defences constitute the first line of defence against intracellular pathogens. The
guanosine triphosphatase RAB32 orchestrates one such defence response against the …

Klebsiella pneumoniae is an important cause of multidrug‐resistant infections worldwide.
Recent studies highlight the emergence of multidrug‐resistant K. pneumoniae strains which …

Phage satellites are bacterial genetic elements that co-opt phage machinery for their own
dissemination. Here we identify a family of satellites, named Phage-Inducible Chromosomal …

Targeted killing of pathogenic bacteria without harming beneficial members of host
microbiota holds promise as a strategy to cure disease and limit both antimicrobial-related …

Random transposon mutagenesis is the strategy of choice for associating a phenotype with
its unknown genetic determinants. It is generally performed by mobilization of a conditionally …

Type VI CRISPR systems protect against phage infection using the RNA-guided nuclease
Cas13 to recognize viral messenger RNA. Upon target recognition, Cas13 cleaves phage …