Friend or foe? The elusive role of hepatic stellate cells in liver cancer
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)
CM Flessa, I Kyrou, N Nasiri‐Ansari… - Journal of Cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …
New insights and potential therapeutic interventions in metabolic diseases
VJ Clemente-Suárez, A Martín-Rodríguez… - International Journal of …, 2023 - mdpi.com
Endocrine homeostasis and metabolic diseases have been the subject of extensive
research in recent years. The development of new techniques and insights has led to a …
research in recent years. The development of new techniques and insights has led to a …
Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
The letter from Hume et al.(2022) argues that the discrete subpopulation of Kupffer cells
(KCs), ie, the liver resident macrophages, that we recently described and named KC2 …
(KCs), ie, the liver resident macrophages, that we recently described and named KC2 …
Inflammatory and immune etiology of type 2 diabetes
Abstract Type 2 diabetes (T2D) represents a global threat affecting millions of patients
worldwide. However, its causes remain incompletely dissected and we lack the tools to …
worldwide. However, its causes remain incompletely dissected and we lack the tools to …
Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge
E Sanchez-Quant, ML Richter, M Colomé-Tatché… - Genome Biology, 2023 - Springer
Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …
Cellular heterogeneity and plasticity during NAFLD progression
HJ Park, J Choi, H Kim, DY Yang, TH An… - Frontiers in Molecular …, 2023 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to
nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma …
nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma …
Interplay between GH-regulated, sex-biased liver transcriptome and hepatic zonation revealed by single-nucleus RNA sequencing
The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2
Granulomas often form around pathogens that cause chronic infections. Here, we discover
an innate granuloma model in mice with an environmental bacterium called …
an innate granuloma model in mice with an environmental bacterium called …
LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by
excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and …
excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and …