Practical guidance for the evaluation and management of drug hypersensitivity: specific drugs

AD Broyles, A Banerji, S Barmettler, CM Biggs… - The Journal of Allergy …, 2020 - Elsevier
Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

Insulin allergy: clinical manifestations and management strategies

L Heinzerling, K Raile, H Rochlitz, T Zuberbier… - Allergy, 2008 - Wiley Online Library
Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is
suspected upon noticing immediate symptoms following insulin injections. The immediate …

Skin signs in diabetes mellitus

B Behm, S Schreml, M Landthaler… - Journal of the …, 2012 - Wiley Online Library
Diabetes mellitus is the most common endocrine disorder with continuously increasing
prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both …

Insulin allergy

MK Ghazavi, GA Johnston - Clinics in dermatology, 2011 - Elsevier
Insulin reactions occur rarely but are of tremendous clinical importance. The first was
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …

Diabetes mellitus and the skin

E Makrantonaki, D Jiang, AM Hossini… - Reviews in Endocrine …, 2016 - Springer
Diabetes is a debilitating, life-threatening disease accounting in 2015 for the death of 5
million people worldwide. According to new estimations, 415 million adults currently suffer …

[PDF][PDF] Delayed hypersensitivity reactions caused by drug excipients: a literature review

ML Caballero, S Quirce - J Investig Allergol Clin Immunol, 2020 - jiaci.org
Abstract The European Medicines Agency (EMA) defines excipients as the constituents of a
pharmaceutical form apart from the active substance. Delayed hypersensitivity reactions …

Place of excipients in systemic drug allergy

A Barbaud - Immunology and Allergy Clinics, 2014 - immunology.theclinics.com
An excipient is an inert substance added to a drug to change dissolution or the kinetics of
absorption, improve stability, influence palatability, or create a distinctive appearance. Also …

[HTML][HTML] Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report

BJ Wheeler, BJ Taylor - Journal of medical case reports, 2012 - Springer
Introduction Insulin allergy to human insulin preparations during the treatment of diabetes is
suggested to occur at rates ranging from< 1.0% to 2.4%. These reactions vary from mild …

A preanodized 6B-pencil graphite as an efficient electrochemical sensor for mono-phenolic preservatives (phenol and meta-cresol) in insulin formulations

N Vishnu, AS Kumar - Analytical Methods, 2015 - pubs.rsc.org
Electrochemical oxidation of phenol on carbon electrodes has often been associated with
problems such as serious adsorption, formation of electro-inactive tarry polymers and …

Severe adverse cutaneous reaction to insulin due to cresol sensitivity

SF Rajpar, IS Foulds, A Abdullah… - Contact …, 2006 - Wiley Online Library
We present the case of an 80‐year‐old lady known to be sensitive to chlorocresol (4‐chloro‐
3‐methyl phenol) who developed severe erythrodermic exfoliative dermatitis with atypical …