Owing to the increase in multidrug‐resistant bacterial isolates in hospitals globally and the
lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have …

New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were
developed. Some synthesized compounds showed excellent bacteriostatic potency; …

A new type of benzopyrone-mediated quinolones (BMQs) was rationally designed and
efficiently synthesized as novel potential antibacterial molecules to overcome the global …

Osteomyelitis is a major complication of orthopedic diseases with high recurrence and
morbidity, along with long hospital stays and high medical costs. The conventional treatment …

With the soaring of bacterial infection and drug resistance, it is imperative to exploit new
efficient antibacterial agents. This work constructed a series of unique phenylhydrazone …

The ongoing emergence of antibiotic-resistant pathogens had been dramatically stimulating
and accelerating the need for new drugs. PE2 is a kind of cyclic lipopeptide with broad …

A class of piperazine hybridized coumarin indolylcyanoenones was exploited as new
structural antibacterial frameworks to combat intractable bacterial resistance. Bioactive …

The rapid dissemination of antibiotic resistance accelerates the desire for new antibacterial
agents. Here, a class of antimicrobial peptides (AMPs) is designed by modifying the …

The emergence of multidrug-resistant bacteria has dramatically increased the lethality, level
of resistance, and difficulty of treatment. In this study, a series of new antimicrobial peptides …