Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
Metastasis prevention: targeting causes and roots
AA Schegoleva, AA Khozyainova… - Clinical & Experimental …, 2022 - Springer
The spread of tumor cells from the primary focus, metastasis, is the main cause of cancer
mortality. Therefore, anticancer therapy should be focused on the prevention of metastatic …
mortality. Therefore, anticancer therapy should be focused on the prevention of metastatic …
[HTML][HTML] The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis
K Ojasalu, S Lieber, AM Sokol, A Nist, T Stiewe… - Theranostics, 2023 - ncbi.nlm.nih.gov
Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade
serous cancer (HGSC) and are associated with short relapse-free survival. LPA is known to …
serous cancer (HGSC) and are associated with short relapse-free survival. LPA is known to …
Influence of the autotaxin-lysophosphatidic acid axis on cellular function and cytokine expression in different breast cancer cell lines
T Hauck, S Kadam, K Heinz, M Garcia Peraza… - Scientific Reports, 2022 - nature.com
Previous studies provide high evidence that autotaxin (ATX)-lysophosphatidic acid (LPA)
signaling through LPA receptors (LPAR) plays an important role in breast cancer initiation …
signaling through LPA receptors (LPAR) plays an important role in breast cancer initiation …
Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl) carbamoyl) piperidin-1-yl)-4 …
C Lescop, C Brotschi, JT Williams… - Journal of Medicinal …, 2024 - ACS Publications
Lysophosphatidic acid receptor 1 (LPAR1) antagonists show promise as potentially novel
antifibrotic treatments. In a human LPAR1 β-arrestin recruitment-based high-throughput …
antifibrotic treatments. In a human LPAR1 β-arrestin recruitment-based high-throughput …
Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases
C Lescop, M Birker, C Brotschi, C Bürki… - Journal of Medicinal …, 2024 - ACS Publications
Piperidine 3 is a potent and selective lysophosphatidic acid receptor subtype 1 receptor
(LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement …
(LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement …
[HTML][HTML] Roles of autotaxin/autotaxin-lysophosphatidic acid axis in the initiation and progression of liver cancer
S She, Q Zhang, J Shi, F Yang, K Dai - Frontiers in Oncology, 2022 - frontiersin.org
Autotaxin (ATX) is a secreted glycoprotein and catalyzes the hydrolysis of
lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling …
lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling …
Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids
Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …
composition and organization of membrane lipids, including the variety of fatty acids they …
The crosstalk of the human microbiome in breast and colon cancer: a metabolomics analysis
AG Mukherjee, UR Wanjari, P Bradu, R Murali… - Critical Reviews in …, 2022 - Elsevier
The human microbiome's role in colon and breast cancer is described in this review.
Understanding how the human microbiome and metabolomics interact with breast and colon …
Understanding how the human microbiome and metabolomics interact with breast and colon …
Integration of an LPAR1 antagonist into liposomes enhances their internalization and tumor accumulation in an animal model of human metastatic breast cancer
Lysophosphatidic acid receptor 1 (LPAR1) is elevated in breast cancer. The deregulation of
LPAR1, including the function and level of expression, is linked to cancer initiation …
LPAR1, including the function and level of expression, is linked to cancer initiation …