Hyperlipidemia and cardiovascular risk in children and adolescents

F Mainieri, S La Bella, F Chiarelli - Biomedicines, 2023 - mdpi.com
Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity
and mortality worldwide. The onset of the atherosclerosis process occurs during childhood …

[HTML][HTML] The role of triglyceride-rich lipoproteins and their remnants in atherosclerotic cardiovascular disease

M Gabani, MD Shapiro, PP Toth - European Cardiology Review, 2023 - ncbi.nlm.nih.gov
Atherosclerotic cardiovascular disease (ASCVD) is the world's leading cause of death.
ASCVD has multiple mediators that therapeutic interventions target, such as dyslipidaemia …

IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

C An, F Sun, C Liu, S Huang, T Xu, C Zhang… - International …, 2023 - Elsevier
Atherosclerosis (AS) is the most common cardiovascular disease and has limited
therapeutic options. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is an …

[HTML][HTML] Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice

P Xiang, Q Chen, L Chen, J Lei, Z Yuan, H Hu, Y Lu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD)
as well as stroke. Endothelial metabolic disorder has been found to be activated and then …

[HTML][HTML] Adipokines regulate mesenchymal stem cell osteogenic differentiation

ZH Xu, CW Xiong, KS Miao, ZT Yu… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) can differentiate into various tissue cell types including
bone, adipose, cartilage, and muscle. Among those, osteogenic differentiation of MSCs has …

Biomimetic nanoparticles for tumor immunotherapy

H Yu, M Wu, S Chen, M Song, Y Yue - Frontiers in bioengineering …, 2022 - frontiersin.org
Currently, tumor treatment research still focuses on the cancer cells themselves, but the fact
that the immune system plays an important role in inhibiting tumor development cannot be …

Relationship of apolipoprotein E with Alzheimer's disease and other neurological disorders: an updated review

T Lou, B Tao, M Chen - Neuroscience, 2023 - Elsevier
Alzheimer's disease (AD) and other neurodegenerative diseases, for which there is no
effective cure, cause great social burden. Apolipoprotein E (APOE) is an important lipid …

[HTML][HTML] The sigma enigma: A narrative review of sigma receptors

J Pergolizzi, G Varrassi, M Coleman, F Breve… - Cureus, 2023 - ncbi.nlm.nih.gov
Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were
thought to be a form of opioid receptors initially. Over time, more was gradually learned …

Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study

KH Yeh, HL Wan, MS Teng, HH Chou, LA Hsu, YL Ko - Genes, 2022 - mdpi.com
Several apolipoprotein genes are located at the APOE locus on chromosome 19q13. 32.
This study explored the genetic determinants of cardiometabolic traits and metabolic …

Protective effect of Panax notoginseng saponins on apolipoprotein-E-deficient atherosclerosis-prone mice

H Yang, Z Liu, X Hu, X Liu, L Gui… - Current pharmaceutical …, 2022 - ingentaconnect.com
Background: It is widely recognized that atherosclerosis (AS) is related to vascular
inflammation. Panax notoginseng saponins (PNS) extracted from the roots of Panax …