Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of
thousands of deaths, especially in children residing in sub-Saharan Africa. Although several …

Plasmodium knowlesi is endemic across Southeast Asia, and is the commonest cause of
zoonotic malaria. The spectrum of clinical disease from P. knowlesi infection ranges from …

BACKGROUND The biology of Plasmodium vivax is markedly different from that of P.
falciparum; how this shapes the immune response to infection remains unclear. To address …

Controlled human malaria infection (CHMI) provides a highly informative means to
investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of …

The spiroindolone cipargamin, a new antimalarial compound that inhibits Plasmodium
ATP4, is currently in clinical development. This study aimed to characterize the antimalarial …

Background The interaction between iron status and malaria is incompletely understood. We
evaluated longitudinal changes in iron homeostasis in volunteers enrolled in malaria …

Introduction Herein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected
individuals (Asym) feature different epidemiological, clinical and biochemical characteristics …

Background New anti-malarial therapeutics are required to counter the threat of increasing
drug resistance. Malaria volunteer infection studies (VIS), particularly the induced blood …

Postoperative recurrence causes a high mortality rate among patients with hepatocellular
carcinoma (HCC). The current study aimed to determine the effects of Plasmodium infection …

Homeostatic perturbation caused by infection fosters two major defense strategies,
resistance and tolerance, which promote the host's survival. Resistance relates to the ability …