Infections have been a major cause of disease throughout the history of humans on earth.
With the introduction of antibiotics, it was thought that infections had been conquered …

This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential
process that provides the organelle with a major oxidative fuel. Although the existence of a …

Reactive oxygen species (ROS), natural by-products of aerobic respiration, are important
cell signaling molecules, which left unchecked can severely impair cellular functions and …

The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is
primarily limited to the cytoplasm of susceptible neuronal populations suggests that …

Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological
roles including: energy provision, membrane structure, cell signaling and regulation of gene …

Mitochondria fulfill a number of biological functions which inherently depend on ATP and O
2−•/H 2 O 2 production. Both ATP and O 2−•/H 2 O 2 are generated by electron transfer …

Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia.
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …

Aldehydes are organic compounds that are widespread in nature. They can be formed
endogenously by lipid peroxidation (LPO), carbohydrate or metabolism ascorbate …

Age has a powerful effect on enhanced susceptibility to neurodegenerative diseases,
including susceptibility to stroke and cognitive impairment (CI) even in optimally healthy …