Leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4) is a member of leukocyte Ig-like
receptors (LILRs), which associate with membrane adaptors to signal through multiple …

Myeloid-derived suppressor cells (MDSCs) are a population of immune suppressive cells
that are involved in tumor-associated immunosuppression, and dominate tumor progression …

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease
characterized by multi-organ injury. However, whether myeloid-derived suppressor cells …

LILRB4, a myeloid inhibitory receptor belonging to the family of leukocyte immunoglobulin-
like receptors (LILRs/LIRs), plays a pivotal role in the regulation of immune tolerance …

The extracellular matrix (ECM) is the basis for virtually all cellular processes and is also
related to tumor metastasis. Fibronectin (FN), a major ECM macromolecule expressed by …

Cutaneous lupus erythematosus (CLE) is a relapsing autoimmune disease, but key
elements that drive disease initiation and progression remain elusive. To date, the lack of …

Abstract LILRB4 (B4, also known as ILT3/CD85k) is an immune checkpoint of myeloid
lineage cells, albeit its mode of function remains obscure. Our recent identification of a …

Natural killer (NK) cells play pivotal roles in innate immunity as well as in anti-tumor
responses via natural killing, while their activity is tightly regulated by cell-surface inhibitory …

A myeloid immune checkpoint, leukocyte immunoglobulin-like receptor (LILR) B4 (B4, also
known as ILT3/CD85k in humans and gp49B in mice) is expressed on dendritic cells (DCs) …

Leukocyte immunoglobulin-like receptor (LILR) B4 (also known as ILT3/CD85k) is an
immune checkpoint protein that is highly expressed in solid tumors and hematological …