Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

S Roy, N Bag, S Bardhan, I Hasan, B Guo - Advanced drug delivery reviews, 2023 - Elsevier
Fluorescence imaging in the second near-infrared window (NIR-II) has become a prevalent
choice owing to its appealing advantages like deep penetration depth, low …

[HTML][HTML] The evolution of fluorescence-guided surgery

S Van Keulen, M Hom, H White, EL Rosenthal… - Molecular Imaging and …, 2023 - Springer
There has been continual development of fluorescent agents, imaging systems, and their
applications over the past several decades. With the recent FDA approvals of 5 …

Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients

R Pal, TM Lwin, M Krishnamoorthy… - Nature Biomedical …, 2023 - nature.com
The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging.
However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the …

Recent advances in chemotherapy-based organic small molecule theranostic reagents

X Rong, C Liu, X Li, H Zhu, K Wang, B Zhu - Coordination Chemistry …, 2022 - Elsevier
The growing number of cancer patients and the limitations of traditional treatments are
forcing researchers to develop more effective treatment methods. Precision medicine with …

[HTML][HTML] Image-guided cancer surgery: a narrative review on imaging modalities and emerging nanotechnology strategies

B Bortot, A Mangogna, G Di Lorenzo, G Stabile… - Journal of …, 2023 - Springer
Surgical resection is the cornerstone of solid tumour treatment. Current techniques for
evaluating margin statuses, such as frozen section, imprint cytology, and intraoperative …

Comparison of fluorescence lifetime and multispectral imaging for quantitative multiplexing in biological tissue

R Pal, ATN Kumar - Biomedical Optics Express, 2022 - opg.optica.org
Fluorescence lifetime (FLT) multiplexing and multispectral imaging (MSI) are both frequently
employed for in vitro and ex vivo biological studies. In vivo applications of MSI for deep …

Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

CS Sia, BT Tey, LE Low - Advanced Functional Materials, 2024 - Wiley Online Library
The integrative use of light and nanoassemblies has made a profound impact in the
biomedical field for diagnosis, drug delivery, and phototherapy. Recent advances in the …

Miniaturized Fab'imaging probe derived from a clinical antibody: characterization and imaging in CRISPRi-attenuated mammary tumor models.

S Gupta, R Pal, EJ Schmidt, M Krishnamoorthy… - iScience, 2024 - cell.com
Clinical imaging-assisted oncosurgical navigation requires cancer-specific miniaturized
optical imaging probes. We report a near-infrared (NIR) Fab'-based epidermal growth factor …

Infrared Fluorescence-guided Surgery for Tumor and Metastatic Lymph Node Detection in Head and Neck Cancer

HW White, AB Naveed, BR Campbell, YJ Lee… - Radiology: Imaging …, 2024 - pubs.rsna.org
In patients with head and neck cancer (HNC), surgical removal of cancerous tissue presents
the best overall survival rate. However, failure to obtain negative margins during resection …

[HTML][HTML] In vivo quantification of programmed death-ligand-1 expression heterogeneity in tumors using fluorescence lifetime imaging

R Pal, K Murali, A Matsui, H Kang, S Morita… - Research …, 2023 - ncbi.nlm.nih.gov
Cancer patient selection for immunotherapy is often based on programmed death-ligand-1
(PD-L1) expression as a biomarker. PD-L1 expression is currently quantified using …