Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Non‐coding RNAs (ncRNAs) have attracted extensive attention due to their vital roles in
tumorigenesis and progression, especially in the immunotherapy resistance. Tumor …

Protein tyrosine phosphatase SHP2 mediates RAS-driven MAPK signaling and has
emerged in recent years as a target of interest in oncology, both for treating with a single …

Colorectal cancers (CRCs) harboring the BRAF (V600E) mutation are associated with
aggressive disease and resistance to BRAF inhibitors by feedback activation of the receptor …

The Programmed death-1 (PD-1) and its programmed death-ligand 1 (PD-L1) comprise the
PD-1/PD-L1 axis and maintain tumor immune evasion. Cancer immunotherapy based on …

Proteins interact with other proteins, with nucleic acids, lipids, carbohydrates and various
small molecules in the living cell. These interactions have been quantified and structurally …

SH2 (Src Homology 2) domains are among the best characterized and most studied protein-
protein interaction (PPIs) modules able to bind and recognize sequences presenting a …

Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment
for patients with ALK-positive lung cancer, but the survival rate beyond 2–3 years is low. Co …

Simple Summary Gene fusions produce chimeric fusion proteins with unpredictable
properties, many of which function as oncogenic drivers. ETV6-NTRK3 produces a …

Simple Summary Pancreatic ductal adenocarcinoma is one of the deadliest malignancies in
humans. Despite advances in systemic therapy, prognosis still remains poor. However …