Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually
every cell type. The transduction of mechanical messages into intracellular biochemical …

In humans, the TRP superfamily of cation channels includes 27 related molecules that
respond to a remarkable variety of chemical and physical stimuli. While physiological roles …

Controlling body temperature is a matter of life or death for most animals, and in mammals
the complex thermoregulatory system is comprised of thermoreceptors, thermosensors, and …

Mechanical and thermal activation of ion channels is central to touch, thermosensation, and
pain. The TRAAK/TREK K 2P potassium channel subfamily produces background currents …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

A workshop of the 2015 International Neuropathic Pain Congress was focused on potassium
channels to propose emerging ideas on the role of these channels on pain modulation and …