White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of …

The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

The β-cells of the islets of Langerhans are embedded in a dense capillary network. The
blood vessels supply the islet cells with nutrients and oxygen, and in turn take up the …

As we previously demonstrated, there is an adaptive increase in insulin secretion in insulin
resistance in the model of high-fat fed female mice. Since it is assumed that islets also adapt …

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and
deliver insulin and glucagon into the circulation. Long believed to be passive conduits of …

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion.
Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

the islet contains a dense vascular structure of several features. the expression of vascular
endothelial growth factor (VEGF)-A in beta cells is indispensable for the formation of this …

Zinc transporter 8 (ZnT8) has been identified as a β-cell-specific Zinc transporter expressed
in insulin-secretory granules. Recent genome wide association studies indicated that …