Aims Changes in the islet vasculature have been implicated in the regulation of β-cell
survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to …

The ultimate goal of diabetes therapy is the restoration of physiologic metabolic control. For
type 1 diabetes, research efforts are focused on the prevention or early intervention to halt …

Background Endoglin/CD105 is an auxiliary receptor for transforming growth factor-β with
established roles in vascular remodelling. It has recently been shown that heterozygous …

Encapsulated beta cell therapy for the treatment of type 1 diabetes remains at the forefront of
biomaterials research. With recent success in generating glucoresponsive stem cell-derived …

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and
deliver insulin and glucagon into the circulation. Long thought to be passive conduits of …

Background Growing evidence from population and clinic based studies showed that
obstructive sleep apnea (OSA) and its characterizing chronic intermittent hypoxia (IH) were …

Pancreatic islets are highly vascularized micro-organs. Approximately 10% of an islet
consists of blood vessels. The induction and maintenance of the islet vascular system …

Abstract<? Pub Inc> R-spondin-1 (Rspo1) is an intestinal growth factor known to exert its
effects through activation of the canonical Wnt (cWnt) pathway, but its function in the [beta] …

Introduction: Fatty liver-associated cardiovascular disease (CVD) is a major cause of
mortality. High fat diets (HFD) induce obesity, insulin resistance, diabetes and non-alcoholic …