The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

G Morris, BK Puri, CC Bortolasci, A Carvalho… - Neuroscience & …, 2021 - Elsevier
Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …

[HTML][HTML] Interdependence of anti-inflammatory and antioxidant properties of squalene–implication for cardiovascular health

NI Ibrahim, I Naina Mohamed - Life, 2021 - mdpi.com
Cardiovascular diseases (CVD) have been recognized as the leading cause of mortality
worldwide, accounting for 31% of global mortality. Among the risk factors of CVD …

[HTML][HTML] Modulatory effect of lifestyle-related, environmental and genetic factors on paraoxonase-1 activity: a review

D Kunachowicz, M Ściskalska, M Kepinska - International Journal of …, 2023 - mdpi.com
Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward
a wide variety of substrates. PON1 displays three types of activities, among which lactonase …

[HTML][HTML] Paraoxonases activities and polymorphisms in elderly and old-age diseases: An overview

D Levy, CO Reichert, SP Bydlowski - Antioxidants, 2019 - mdpi.com
Aging is defined as the accumulation of progressive organ dysfunction. There is much
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …

Antiepileptic drugs: impacts on human serum paraoxonase‐1

Ş Beydemir, Y Demir - Journal of biochemical and molecular …, 2017 - Wiley Online Library
Serum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐
cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL …

Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities

S Loued, H Berrougui, P Componova… - British Journal of …, 2013 - cambridge.org
Paraoxonase 1 (PON1) is associated with HDL and modulates the antioxidant and anti-
inflammatory role of HDL. The goals of the present study were to investigate the effect of …

Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat

R Kumar, F Akhtar, SI Rizvi - Clinical and experimental …, 2020 - Wiley Online Library
Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An
altered lipid profile is a major factor responsible for the development of CVD. Male Wistar …

Onion extract (Allium cepa L.), quercetin and catechin up‐regulate paraoxonase 1 activity with concomitant protection against low‐density lipoprotein oxidation in …

N Jaiswal, SI Rizvi - Journal of the Science of Food and …, 2014 - Wiley Online Library
Abstract BACKGROUND Paraoxonase 1 (PON1) protects the oxidative modification of low‐
density lipoprotein (LDL) and is a major anti‐atherosclerotic protein component of high …

Hesperidin supplementation improves altered PON-1, LDL oxidation, inflammatory response and hepatic function in an experimental rat model of hyperlipidemia

R Kumar, MI Khan, F Ashfaq, AA Alsayegh… - Indian Journal of Clinical …, 2024 - Springer
In this study, we have examined the effect of hesperidin on rats fed on an experimental high-
fat diet. Male Wistar rats were given a high-fat diet orally for one month for developing an …

[HTML][HTML] Decreases in paraoxonase-1 activities promote a pro-inflammatory effect of lipids peroxidation products in non-smoking and smoking patients with acute …

G Marek, M Ściskalska, Z Grzebieniak… - International Journal of …, 2018 - ncbi.nlm.nih.gov
Aim: The study investigated the extent to which tobacco smoke exposure causes changes in
lipids biochemistry through measurement blood concentrations of: paraoxonase-1 (PON-1) …