Homeostatic regulation of metabolic fuels involves the generally opposing actions of insulin
and glucagon. As most agents simultaneously affect secretion of both hormones, this review …

The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle
comprised of a many proteins with different catalytic activities and messenger functions. With …

The behaviour of proinsulin and insulin in the presence of zinc suggests it plays an
important role in insulin's production in the B-cell for the vast majority of animal species. The …

In view of the known effect of zinc on the crystalline nature of insulin, we have investigated
whether zinc alters the biologic potency of this hormone. Using the rate of lipogenesis by rat …

Beta cells from nondiabetic mice transfer secretory vesicles to phagocytic cells. The passage
was shown in culture studies where the transfer was probed with CD4 T cells reactive to …

Publisher Summary This chapter discusses the implications in metabolic regulation because
of the concentrations of metabolites and binding sites. One important property of biological …

Concomitant with glucose-induced insulin release, there occurred an increase of ATP from
4.40±0.21 to 23.16±0.52 pmol/100 islets/min (P< 0.001) in the effluent from perifused rat …

Rat pancreatic islets contain aspartate aminotransferase and malate dehydrogenase,
enzymes necessary for the malate aspartate hydrogen shuttle, in both the cytosolic and …

Energy metabolism in islets of Langerhans Page 1 Biochmtica et Btophysica Acta. I101 (10921
273-295 273 ~, 1902 Elsevier Science Publishers BV All righls rescm'cd 01N)5-272N/'92/$OS,(IU …

Experiments were designed to study the effect of Zn on in vivo and in vitro insulin
metabolism. The in vivo experiments involved pretreating mice with either Zn or Na, followed …