Adenine nucleotides are thought to serve as second messengers in the control of beta-cell
function by glucose, eg by regulating the activity of ATP-dependent K+ channels. However …

,, Yes, I have a pair of eyes" replied Sam,, and that's just it. If they wos a pair o'patent double
million magnifln'gas microscopes of hextra power, p'raps I might be able to see through a …

A lysed crude secretory granule fraction from rat islets of Langerhans was shown to process
endogenous proinsulin to insulin with a pH optimum of 5.0--6.0. The converting activity in the …

Proinsulin is converted to insulin in an impure secretion granule fraction prepared from rat
islets of Langerhans that have been labeled before homogenization with [3 H] leucine or [3 …

Regulated secretion is conserved in all eukaryotes. In vertebrates granin family proteins
function in all key steps of regulated secretion. Phase separation and amyloid-based …

Amyloids are highly organized cross β-sheet protein nanofibrils that are associated with both
diseases and functions. Thermodynamically amyloids are stable structures as they represent …

The distribution of radioautographic grains over organelles within the beta cells of rat islets
of Langerhans was investigated at various times after pulse labeling of the isolated islets …

Publisher Summary This chapter presents the concept of the involvement of the microtubular-
microfilamentous system in the intracellular transport of beta granules and the mechanism …

A partially purified secretory granule fraction, isolated from rat islets of Langerhans by
differential centrifugation, was used for investigating the stability of the beta granules during …

Calcium concentrations of various pancreatic B cell organelles have been determined by X-
ray microanalysis of areas of frozen sections of unfixed rat islets of Langerhans. Highest …