Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar
degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate …

Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …

Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …

Several studies using cryogenic electron microscopy (cryo-EM) techniques recently reported
the isolation and characterization of novel protein filaments, composed of a C-terminal …

Background The risk for dementia increases exponentially from the seventh decade of life.
Identifying and understanding the biochemical changes that sensitize the ageing brain to …

Dear Editor, Protein amyloid aggregation is a histological hallmark of neurodegenerative
diseases (NDs). 1, 2 In synucleinopathies including ParkinsonLs disease (PD), ParkinsonLs …

TMEM106B, a lysosomal transmembrane protein, has been closely associated with brain
health. Recently, an intriguing link between TMEM106B and brain inflammation has been …