Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

Parasitic diseases still pose a serious threat to human and animal health, particularly for
millions of people and their livelihoods in low-income countries. Therefore, research into the …

The eradication of malaria will only be possible if effective, well-tolerated medicines kill
hypnozoites in vivax and ovale malaria, and thus prevent relapses in patients. Despite …

Human malaria, one of the most striking, reemerging infectious diseases, is caused by
several types of Plasmodium parasites. Whilst advances have been made in lowering the …

Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually with over 500,000 deaths. Among the NTDs, some of the …

Avermectins are powerful endectocides with an established potential to reduce the
incidence of vector-borne diseases. Here, we show that several avermectins inhibit the …

Ivermectin is a sixteen-membered macrolactone “wonder drug” of Nobel prize-honored
distinction that exhibits a wide range of antiparasitic activities. It has been used for almost …

Abstract According to WHO World Malaria Report (2018), nearly 219 million new cases of
malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious …

In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors
containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235) …

Our previous work found that the clinical histone deacetylase (HDAC) inhibitor quisinostat
exhibited a significant antimalarial effect but with severe toxicity. In this work, 35 novel …