[HTML][HTML] Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics

SA Nixon, C Welz, DJ Woods, L Costa-Junior… - International Journal for …, 2020 - Elsevier
Control of helminth parasites is a key challenge for human and veterinary medicine. In the
absence of effective vaccines and adequate sanitation, prophylaxis and treatment commonly …

Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes

M Zajíčková, LT Nguyen, L Skálová, LR Stuchlíková… - Drug Discovery …, 2020 - Elsevier
Highlights•Gastrointestinal nematodes are resistant to available anthelmintics.•No new
anthelmintic on the market for several years.•A target-based approach, drug repurposing or …

Natural products are a promising source for anthelmintic drug discovery

KLTD Jayawardene, EA Palombo, PR Boag - Biomolecules, 2021 - mdpi.com
Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of
the major causative factors for physical and intellectual growth retardation in the developing …

An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

AA Elkordy, RR Haj-Ahmad, AS Awaad… - Journal of Drug Delivery …, 2021 - Elsevier
For decades, naturally produced plants have been studied and used in herbalism (herbal
medicines). Despite being natural, these products were not of any interest of any of the …

Potential New Therapeutic Approaches Based on Punica granatum Fruits Compared to Synthetic Anthelmintics for the Sustainable Control of Gastrointestinal …

F Castagna, R Bava, V Musolino, C Piras… - Animals, 2022 - mdpi.com
Simple Summary The spread of helminths resistant to the most common classes of
anthelmintic drugs in sheep and the presence of drug residues in the environment has …

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

J Sharifi-Rad, F Kobarfard, A Ata, SA Ayatollahi… - Biomolecules, 2019 - mdpi.com
Members of the Prosopis genus are native to America, Africa and Asia, and have long been
used in traditional medicine. The Prosopis species most commonly used for medicinal …

Green Veterinary Pharmacology Applied to Parasite Control: Evaluation of Punica granatum, Artemisia campestris, Salix caprea Aqueous Macerates against …

F Castagna, C Piras, E Palma, V Musolino, C Lupia… - Veterinary …, 2021 - mdpi.com
Resistance to anthelmintic drugs in gastrointestinal nematodes (GIN) of sheep is of high
concern for livestock production worldwide. In Calabria (southern Italy), many plants have …

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

SRM Ibrahim, SGA Mohamed, BH Alsaadi… - Marine Drugs, 2023 - mdpi.com
Marine-derived fungi are renowned as a source of astonishingly significant and synthetically
appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical …

[HTML][HTML] Antifungal natural products and their derivatives: A review of their activity and mechanism of actions

CW Zhang, XJ Zhong, YS Zhao, MSR Rajoka… - Pharmacological …, 2023 - Elsevier
Introduction Secondary metabolites, also called specialized metabolites, are essential in
defense and cell-to-cell communication that play a significant role in pharmacotherapy …

Natural products as anthelmintics: safeguarding animal health

AA Salim, MS Butler, MAT Blaskovich… - Natural Product …, 2023 - pubs.rsc.org
Covering literature to December 2022This review provides a comprehensive account of all
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …