[HTML][HTML] Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics
SA Nixon, C Welz, DJ Woods, L Costa-Junior… - International Journal for …, 2020 - Elsevier
Control of helminth parasites is a key challenge for human and veterinary medicine. In the
absence of effective vaccines and adequate sanitation, prophylaxis and treatment commonly …
absence of effective vaccines and adequate sanitation, prophylaxis and treatment commonly …
Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes
M Zajíčková, LT Nguyen, L Skálová, LR Stuchlíková… - Drug Discovery …, 2020 - Elsevier
Highlights•Gastrointestinal nematodes are resistant to available anthelmintics.•No new
anthelmintic on the market for several years.•A target-based approach, drug repurposing or …
anthelmintic on the market for several years.•A target-based approach, drug repurposing or …
Natural products are a promising source for anthelmintic drug discovery
Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of
the major causative factors for physical and intellectual growth retardation in the developing …
the major causative factors for physical and intellectual growth retardation in the developing …
An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future
AA Elkordy, RR Haj-Ahmad, AS Awaad… - Journal of Drug Delivery …, 2021 - Elsevier
For decades, naturally produced plants have been studied and used in herbalism (herbal
medicines). Despite being natural, these products were not of any interest of any of the …
medicines). Despite being natural, these products were not of any interest of any of the …
Potential New Therapeutic Approaches Based on Punica granatum Fruits Compared to Synthetic Anthelmintics for the Sustainable Control of Gastrointestinal …
Simple Summary The spread of helminths resistant to the most common classes of
anthelmintic drugs in sheep and the presence of drug residues in the environment has …
anthelmintic drugs in sheep and the presence of drug residues in the environment has …
Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence
J Sharifi-Rad, F Kobarfard, A Ata, SA Ayatollahi… - Biomolecules, 2019 - mdpi.com
Members of the Prosopis genus are native to America, Africa and Asia, and have long been
used in traditional medicine. The Prosopis species most commonly used for medicinal …
used in traditional medicine. The Prosopis species most commonly used for medicinal …
Green Veterinary Pharmacology Applied to Parasite Control: Evaluation of Punica granatum, Artemisia campestris, Salix caprea Aqueous Macerates against …
Resistance to anthelmintic drugs in gastrointestinal nematodes (GIN) of sheep is of high
concern for livestock production worldwide. In Calabria (southern Italy), many plants have …
concern for livestock production worldwide. In Calabria (southern Italy), many plants have …
Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii
SRM Ibrahim, SGA Mohamed, BH Alsaadi… - Marine Drugs, 2023 - mdpi.com
Marine-derived fungi are renowned as a source of astonishingly significant and synthetically
appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical …
appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical …
[HTML][HTML] Antifungal natural products and their derivatives: A review of their activity and mechanism of actions
CW Zhang, XJ Zhong, YS Zhao, MSR Rajoka… - Pharmacological …, 2023 - Elsevier
Introduction Secondary metabolites, also called specialized metabolites, are essential in
defense and cell-to-cell communication that play a significant role in pharmacotherapy …
defense and cell-to-cell communication that play a significant role in pharmacotherapy …
Natural products as anthelmintics: safeguarding animal health
Covering literature to December 2022This review provides a comprehensive account of all
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …