[HTML][HTML] Central roles of STAT3-mediated signals in onset and development of cancers: tumorigenesis and immunosurveillance

S Hashimoto, A Hashimoto, R Muromoto, Y Kitai… - Cells, 2022 - mdpi.com
Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …

[HTML][HTML] Current treatments for non-small cell lung cancer

Q Guo, L Liu, Z Chen, Y Fan, Y Zhou, Z Yuan… - Frontiers in …, 2022 - frontiersin.org
Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …

[HTML][HTML] Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes

X Jin, B Shang, J Wang, J Sun, J Li, B Liang… - Cell Death & …, 2024 - nature.com
Metastasis accounts for the majority of cases of cancer recurrence and death in patients with
advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid …

Exosomal miR-21 determines lung-to-brain metastasis specificity through the DGKB/ERK axis within the tumor microenvironment

TY Tiong, M Chan, CH Wang, VK Yadav, NW Pikatan… - Life Sciences, 2023 - Elsevier
Abstract Background Brain metastasis affects 20–40% of lung cancer patients, severely
diminishing their quality of life. This research focuses on miR-21, overexpressed in these …

[HTML][HTML] Insights into the mechanisms of action of proanthocyanidins and anthocyanins in the treatment of nicotine-induced non-small cell lung cancer

NA Alsharairi - International journal of molecular sciences, 2022 - mdpi.com
In traditional medicine, different parts of plants, including fruits, have been used for their anti-
inflammatory and anti-oxidative properties. Plant-based foods, such as fruits, seeds and …

[HTML][HTML] Nanoparticle-mediated delivery of STAT3 inhibitors in the treatment of lung cancer

Q Feng, K Xiao - Pharmaceutics, 2022 - mdpi.com
Lung cancer is a common malignancy worldwide, with high morbidity and mortality. Signal
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …

Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery

Y Sun, D Yu, X Geng, D Ding, Y Yang… - … Applied Materials & …, 2023 - ACS Publications
RNA interference (RNAi) mediated by short interfering RNA (siRNA) is a promising method
for cancer treatment, but the clinical application is hampered by several limitations, including …

[HTML][HTML] The chemokine CCL4 stimulates angiopoietin-2 expression and angiogenesis via the MEK/ERK/STAT3 pathway in oral squamous cell carcinoma

CC Lu, HC Tsai, DY Yang, SW Wang, MH Tsai… - Biomedicines, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with a poor prognosis
and is a major public health burden in Taiwan. Angiogenesis, the formation of new blood …

[HTML][HTML] Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

RE Kast, A Alfieri, HI Assi, TC Burns, AM Elyamany… - Cancers, 2022 - mdpi.com
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

RY Shahrivar, ZA Fakhr… - Advanced …, 2023 - Wiley Online Library
Lung cancer remains the leading cause of cancer‐related deaths worldwide, and
conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are …