[HTML][HTML] Central roles of STAT3-mediated signals in onset and development of cancers: tumorigenesis and immunosurveillance
S Hashimoto, A Hashimoto, R Muromoto, Y Kitai… - Cells, 2022 - mdpi.com
Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …
associated inflammation contributes to tumor initiation and progression. However, it remains …
[HTML][HTML] Current treatments for non-small cell lung cancer
Q Guo, L Liu, Z Chen, Y Fan, Y Zhou, Z Yuan… - Frontiers in …, 2022 - frontiersin.org
Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …
[HTML][HTML] Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes
X Jin, B Shang, J Wang, J Sun, J Li, B Liang… - Cell Death & …, 2024 - nature.com
Metastasis accounts for the majority of cases of cancer recurrence and death in patients with
advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid …
advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid …
Exosomal miR-21 determines lung-to-brain metastasis specificity through the DGKB/ERK axis within the tumor microenvironment
TY Tiong, M Chan, CH Wang, VK Yadav, NW Pikatan… - Life Sciences, 2023 - Elsevier
Abstract Background Brain metastasis affects 20–40% of lung cancer patients, severely
diminishing their quality of life. This research focuses on miR-21, overexpressed in these …
diminishing their quality of life. This research focuses on miR-21, overexpressed in these …
[HTML][HTML] Insights into the mechanisms of action of proanthocyanidins and anthocyanins in the treatment of nicotine-induced non-small cell lung cancer
NA Alsharairi - International journal of molecular sciences, 2022 - mdpi.com
In traditional medicine, different parts of plants, including fruits, have been used for their anti-
inflammatory and anti-oxidative properties. Plant-based foods, such as fruits, seeds and …
inflammatory and anti-oxidative properties. Plant-based foods, such as fruits, seeds and …
[HTML][HTML] Nanoparticle-mediated delivery of STAT3 inhibitors in the treatment of lung cancer
Q Feng, K Xiao - Pharmaceutics, 2022 - mdpi.com
Lung cancer is a common malignancy worldwide, with high morbidity and mortality. Signal
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …
transducer and activator of transcription 3 (STAT3) is an important transcription factor that …
Artificial Base-Directed In Vivo Assembly of an Albumin–siRNA Complex for Tumor-Targeting Delivery
RNA interference (RNAi) mediated by short interfering RNA (siRNA) is a promising method
for cancer treatment, but the clinical application is hampered by several limitations, including …
for cancer treatment, but the clinical application is hampered by several limitations, including …
[HTML][HTML] The chemokine CCL4 stimulates angiopoietin-2 expression and angiogenesis via the MEK/ERK/STAT3 pathway in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with a poor prognosis
and is a major public health burden in Taiwan. Angiogenesis, the formation of new blood …
and is a major public health burden in Taiwan. Angiogenesis, the formation of new blood …
[HTML][HTML] Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …
a more effective treatment than we currently have. To do this we outline why a regimen …
Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions
RY Shahrivar, ZA Fakhr… - Advanced …, 2023 - Wiley Online Library
Lung cancer remains the leading cause of cancer‐related deaths worldwide, and
conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are …
conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are …