Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with
several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and …

Research on tumour cell‐derived small extracellular vesicles (sEVs) that regulate tumour
microenvironment (TME) has provided strategies for targeted therapy of head and neck …

Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …

Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme in
polyunsaturated fatty acid (PUFA) metabolism. The role of ACSL4 in the lipopolysaccharide …

The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

The adenosine A2A receptor subtype is recognized as a non-dopaminergic
pharmacological target for the treatment of neurodegenerative disorders, notably …

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …