Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

The primary female sex hormones, estrogens, are responsible for the control of functions of
the female reproductive system, as well as the development of secondary sexual …

Background Repurposing is a drug development strategy receiving heightened attention
after the Food and Drug Administration granted emergency use authorization of several …

The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

Background A phase 2 study showed that progression-free survival was longer with
palbociclib plus letrozole than with letrozole alone in the initial treatment of postmenopausal …

Hormones regulate homeostasis by communicating through the bloodstream to the body's
organs, including the brain. As homeostatic regulators of brain function, some hormones …

Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

Breast cancer is the second leading cause of death for women worldwide. While
monotherapy (single agent) treatments have been used for many years, they are not always …

Purpose: Preclinical data identified the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor
palbociclib as synergistic with antiestrogens in inhibiting growth of hormone receptor …

A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …