The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …

Error-free chromosome segregation relies on stable connections between kinetochores and
spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections …

In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother
cell, sister chromatids in the mother cell must attach to microtubules emanating from …

Nuclear pore complexes (NPCs) regulate nuclear-cytoplasmic transport, transcription, and
genome integrity in eukaryotic cells. However, their functional roles in cancer remain poorly …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …