Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

M Gawałko, A Saljic, N Li, I Abu-Taha… - Cardiovascular …, 2023 - academic.oup.com
Obesity is an important contributing factor to the pathophysiology of atrial fibrillation (AF) and
its complications by causing systemic changes, such as altered haemodynamic, increased …

Role of RIPK3‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases

S Chen, S Guan, Z Yan, F Ouyang… - International …, 2023 - spandidos-publications.com
Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny
and the maintenance of homeostasis. In the last decade, it has been demonstrated that the …

Hybrid nanogenerator based closed-loop self-powered low-level vagus nerve stimulation system for atrial fibrillation treatment

Y Sun, S Chao, H Ouyang, W Zhang, W Luo, Q Nie… - Science Bulletin, 2022 - Elsevier
Atrial fibrillation is an “invisible killer” of human health. It often induces high-risk diseases,
such as myocardial infarction, stroke, and heart failure. Fortunately, atrial fibrillation can be …

[HTML][HTML] Potential mechanism underlying exercise upregulated circulating blood exosome miR-215-5p to prevent necroptosis of neuronal cells and a model for early …

Y Chen, Y Sun, Z Luo, J Lin, B Qi, X Kang… - Frontiers in Aging …, 2022 - frontiersin.org
Exercise is crucial for preventing Alzheimer's disease (AD), although the exact underlying
mechanism remains unclear. The construction of an accurate AD risk prediction model is …

Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and …

Y Zhang, Y Fu, T Jiang, B Liu, H Sun, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its
pathogenesis was associated with metabolic disorder, especially defective fatty acids …

Effects of inflammatory cell death caused by catheter ablation on atrial fibrillation

D Liu, Y Li, Q Zhao - Journal of Inflammation Research, 2023 - Taylor & Francis
Atrial fibrillation (AF) poses a serious healthcare burden on society due to its high morbidity
and the resulting serious complications such as thrombosis and heart failure. The principle …

Restoring the autonomic balance in an atrial fibrillation rat model by electroacupuncture at the neiguan point

Y Su, J Huang, S Sun, T He, T Wang, M Fan… - … : Technology at the …, 2022 - Elsevier
Objectives Autonomic nervous activity imbalance plays an important role in atrial fibrillation
(AF). AF can be treated by acupuncture at the Neiguan point (PC6), but the mechanism …

Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis

J Adhikari, T Hirai, E Kawakita, K Iwai… - Journal of Diabetes …, 2023 - Wiley Online Library
ABSTRACT Aims/Introduction Linagliptin is a selective dipeptidyl peptidase (DPP)‐4
inhibitor capable of successfully regulating blood glucose levels. The cardiovascular …

Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload

X Qin, Y Fu, J Fan, B Liu, P Liu, Y Zhang… - Journal of Pineal …, 2023 - Wiley Online Library
Melatonin has been proven to have antiarrhythmic potential; however, several studies have
recently challenged this view. Herein, using a mouse model of obesity‐induced atrial …

Targeting necroptosis in fibrosis

EHM Hassanein, IM Ibrahim… - Molecular Biology …, 2023 - Springer
Necroptosis, a type of programmed cell death that resembles necrosis, is now known to
depend on a different molecular mechanism from apoptosis, according to several recent …